High-Resolution Recombination Map in Drosophila melanogaster
The Comeron Lab

Recombination is a fundamental biological process. Evolutionarily, recombination is predicted to increase the effectiveness of selection in natural populations, thus explaining the pervasiveness of recombination and sex. In most species, recombination rates also vary among and along chromosomes. This intra-genomic variation provides a unique opportunity to evaluate the evolutionary consequences of recombination due to exposure to identical demographic and environmental factors; an all else being equal premise that is hardly ever warranted when comparing populations or species. The recombination rate is also a central parameter in population genetic analyses designed to assess the presence and mode of selection across genomes. Evolutionary analyses, however, can be hindered by the use of imprecise recombination rates that can influence the results and/or skew their interpretation.

We generated high-resolution, whole-genome maps of crossing-over (CO) in D. melanogaster by genotyping a total of 139 million informative SNPs, with 32,511 CO events mapped at a resolution down to 2 kilobases. These maps are shown here at the scale of 100-kb.

How to Cite and Details: Comeron JM, R. Ratnappan and S. Bailin. The many landscapes of recombination in Drosophila melanogaster. PLoS Genet. 2012 Sep;8(10):e1002905.